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Table 3 Therapeutic information of the drugs assigned to the baseline class that were scored highest by the HIV model a

From: Exploiting large-scale drug-protein interaction information for computational drug repurposing

Generic name Score Information from DrugBankb Information from other sources
Verapamil 23.5 For hypertension, angina, and cluster headache prophylaxis. A 1991 study [37] observed that verapamil at high concentration can potentiate HIV-1 replication in lymphoid cells.
Clotrimazole 22.6 For oropharyngeal candidiasis, vaginal yeast infections, and fungal infections.  
Ketoconazole 21.5 For fungal infections.  
Dexamethasone 21.0 An anti-inflammatory 9-fluoro-glucocorticoid. A 2001 study [36] found that dexamethasone inhibits CD4 T cell death mediated by macrophages from HIV-infected persons.
Amprenavir 19.6 For treatment of HIV-1 infection in combination with other antiretroviral agents.  
Atorvastatin 19.3 For hypercholesterolemia. A 2004 study [35] concluded that statins inhibit HIV-1 infection by downregulating Rho activity.
Clarithromycin 18.5 Antibiotic.  
Lovastatin 18.2 For hypercholesterolemia. A 2004 study [35] concluded that statins inhibit HIV-1 infection by downregulating Rho activity.
Quinidine barbiturate 18.1 For the treatment of ventricular pre-excitation and cardiac dysrhythmias.  
Cimetidine 17.9 For acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.  
  1. aThe model was developed with all 20 HIV drugs in the FDA’s HIV drug list in the positive class; the remaining compounds were potential repurposing candidates in the baseline class.
  2. bRef. [26].