Table 3 Therapeutic information of the drugs assigned to the baseline class that were scored highest by the HIV model a
From: Exploiting large-scale drug-protein interaction information for computational drug repurposing
Generic name | Score | Information from DrugBankb | Information from other sources |
|---|---|---|---|
Verapamil | 23.5 | For hypertension, angina, and cluster headache prophylaxis. | A 1991 study [37] observed that verapamil at high concentration can potentiate HIV-1 replication in lymphoid cells. |
Clotrimazole | 22.6 | For oropharyngeal candidiasis, vaginal yeast infections, and fungal infections. | |
Ketoconazole | 21.5 | For fungal infections. | |
Dexamethasone | 21.0 | An anti-inflammatory 9-fluoro-glucocorticoid. | A 2001 study [36] found that dexamethasone inhibits CD4 T cell death mediated by macrophages from HIV-infected persons. |
Amprenavir | 19.6 | For treatment of HIV-1 infection in combination with other antiretroviral agents. | |
Atorvastatin | 19.3 | For hypercholesterolemia. | A 2004 study [35] concluded that statins inhibit HIV-1 infection by downregulating Rho activity. |
Clarithromycin | 18.5 | Antibiotic. | |
Lovastatin | 18.2 | For hypercholesterolemia. | A 2004 study [35] concluded that statins inhibit HIV-1 infection by downregulating Rho activity. |
Quinidine barbiturate | 18.1 | For the treatment of ventricular pre-excitation and cardiac dysrhythmias. | |
Cimetidine | 17.9 | For acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. |