SNP detection sensitivity in exome and whole genome sequencing. Exome and whole genome sequencing mapped read depth across the exons of an example gene. The grey vertical lines denote exon boundaries. At point A, the depth is equal and we can compare the per-site SNP detection sensitivity. Points B and C are examples of unequal depth, where per-site sensitivity cannot be directly compared, but the overall estimated sensitivity of the region can be calculated to account for the variability in coverage.