Noise and imprecision quantification. The color map indicates the probability that the actual causative gene rank, R, is less than or equal to r (y-axis) given the similarity value, S (x-axis), between the actual and optimal patient, that is the similarity between the patient terms with noise and/or imprecision, P
, and the corresponding optimal patient terms, P
. Similarity values are normalized by the self-similarity between the optimal patient terms so that all values of S are in [0,1].