Figure 1

An example of the stem cell differentiation program execution. The program was executed up to simulation time 100 days. (A) Schematic representation of the eSTG rules (without rates and probabilities). (B) Population size over time of a specific execution. (C) Cell lineage tree of a specific execution (only one cell lineage tree out of the originating SCs and Diffs is shown). (D) Average population size over time (calculated from 1000 stochastic executions). (E) Clone size distribution, which is the final population size derived from each initiating individual (calculated from 1000 stochastic executions).