Skip to main content

Table 6 Predicted interactions found from biclusters constructed using rows as viral proteins and columns as human proteins (Sl. No. 1 to 26) and rows as human proteins and columns as viral proteins (Sl. No. 27 to 36)

From: Incorporating the type and direction information in predicting novel regulatory interactions between HIV-1 and human proteins using a biclustering approach

Sl. No. HIV-1 Protein Human protein Interaction types Pubmed Id
1 Tat CD4 DOWNREGULATES 22421574, 22342181
2 Tat MAPK14 ACTIVATES 20378550
3 Tat CASP9 ACTIVATES 11509621
4 Tat CASP3 ACTIVATES 17505978
5 Tat IL6 UPREGULATES 17151125, 9169458
6 Tat CD4 INTERACTS WITH 12457987
7 Tat PARP1 INDUCES CLEAVAGE OF 15498776
8 Tat BCL2 DOWNREGULATES 11994280
9 Nef JUN ACTIVATES 12419805
10 Nef FOS ACTIVATES 20068037, 10388555
11 Nef MAPK1 ACTIVATES 21738584
12 Nef LCK ACTIVATES 16849330
13 Nef CASP3 ACTIVATES 11123279
14 Nef IFNG DOWNREGULATES 21858117
15 Nef BCL2 DOWNREGULATES 15858021
16 Nef CCL3 DOWNREGULATES 20015995
17 Nef IL12B UPREGULATES 19019824
18 Nef IL6 UPREGULATES 11519483, 8799208
19 matrix IL10 UPREGULATES 18178611
20 matrix IL1B UPREGULATES 18593760
21 matrix IL2 DOWNREGULATES 21482826
22 env_gp120 CASP3 ACTIVATES 16330530
23 env_gp120 CD4 DOWNREGULATES 22226668
24 env_gp160 TNF UPREGULATES 8938574
25 Vpu BC+L2 DOWNREGULATES 11696595
26 env_gp120 MAPK8 ACTIVATES 11468147
27 env_gp120 TNF INHIBITS 16873189
28 Tat NFKBIA UPREGULATES 22187158
29 Tat IFNB1 UPREGULATES 9223731
30 Tat CXCR4 INTERACTS WITH 11594685
31 Tat CCL3 UPREGULATES 15204927
32 Nef NFKB1 INTERACTS WITH 12419805
33 Nef BCL2L1 DOWNREGULATES 11123279
34 Vpr CASP9 ACTIVATES 12096338
35 Vpr CYCS INDUCES RELEASE OF 16511342
  1. Direction of the regulations are taken from viral to human proteins.