Incorporating the type and direction information in predicting novel regulatory interactions between HIV-1 and human proteins using a biclustering approach

Table 6 Predicted interactions found from biclusters constructed using rows as viral proteins and columns as human proteins (Sl. No. 1 to 26) and rows as human proteins and columns as viral proteins (Sl. No. 27 to 36)

Sl. No.	HIV-1 Protein	Human protein	Interaction types	Pubmed Id
1	Tat	CD4	DOWNREGULATES	22421574, 22342181
2	Tat	MAPK14	ACTIVATES	20378550
3	Tat	CASP9	ACTIVATES	11509621
4	Tat	CASP3	ACTIVATES	17505978
5	Tat	IL6	UPREGULATES	17151125, 9169458
6	Tat	CD4	INTERACTS WITH	12457987
7	Tat	PARP1	INDUCES CLEAVAGE OF	15498776
8	Tat	BCL2	DOWNREGULATES	11994280
9	Nef	JUN	ACTIVATES	12419805
10	Nef	FOS	ACTIVATES	20068037, 10388555
11	Nef	MAPK1	ACTIVATES	21738584
12	Nef	LCK	ACTIVATES	16849330
13	Nef	CASP3	ACTIVATES	11123279
14	Nef	IFNG	DOWNREGULATES	21858117
15	Nef	BCL2	DOWNREGULATES	15858021
16	Nef	CCL3	DOWNREGULATES	20015995
17	Nef	IL12B	UPREGULATES	19019824
18	Nef	IL6	UPREGULATES	11519483, 8799208
19	matrix	IL10	UPREGULATES	18178611
20	matrix	IL1B	UPREGULATES	18593760
21	matrix	IL2	DOWNREGULATES	21482826
22	env_gp120	CASP3	ACTIVATES	16330530
23	env_gp120	CD4	DOWNREGULATES	22226668
24	env_gp160	TNF	UPREGULATES	8938574
25	Vpu	BC+L2	DOWNREGULATES	11696595
26	env_gp120	MAPK8	ACTIVATES	11468147
27	env_gp120	TNF	INHIBITS	16873189
28	Tat	NFKBIA	UPREGULATES	22187158
29	Tat	IFNB1	UPREGULATES	9223731
30	Tat	CXCR4	INTERACTS WITH	11594685
31	Tat	CCL3	UPREGULATES	15204927
32	Nef	NFKB1	INTERACTS WITH	12419805
33	Nef	BCL2L1	DOWNREGULATES	11123279
34	Vpr	CASP9	ACTIVATES	12096338
35	Vpr	CYCS	INDUCES RELEASE OF	16511342

ISSN: 1471-2105