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Table 3 Gene sets with LCT p-values for multiple phenotypes ( LEP , ADIPOQ ) less than 0.05, while p-values for univariate phenotype LEP and ADIPOQ are larger than 0.05

From: Gene set enrichment analysis for multiple continuous phenotypes

Gene-set name Gene-set size LEP p-value ADIPOQp-value ( ADIPOQ, LEP) p-value
YEN_MYC_WT 8 0.061 0.199 0.034
GLUCONEOGENESIS 50 0.195 0.192 0.036
BYSTRYKH_HSC_BRAIN_TRANS_GLOCUS 144 0.118 0.157 0.047
PENG_LEUCINE_DN 135 0.186 0.189 0.035
AMINOSUGARS_METABOLISM 14 0.223 0.341 0.039
PENTOSE_PHOSPHATE_PATHWAY 21 0.192 0.098 0.044
ZELLER_MYC_UP 22 0.09 0.262 0.032
POMEROY_DESMOPLASIC_VS_CLASSIC_MD_DN 38 0.093 0.079 0.011
FBW7PATHWAY 8 0.088 0.314 0.048
GSK3PATHWAY 24 0.18 0.225 0.028
GOLDRATH_CELLCYCLE 31 0.21 0.105 0.048
STREPTOMYCIN_BIOSYNTHESIS 8 0.094 0.072 0.013
FRUCTOSE_AND_MANNOSE_METABOLISM 24 0.168 0.061 0.007
GLYCOLYSISPATHWAY 8 0.137 0.076 0.013
UBIQUINONE_BIOSYNTHESIS 12 0.086 0.051 0.013
HOFMANN_MANTEL_LYMPHOMA_VS_LYMPH_NODES_UP 45 0.053 0.135 0.022
HOGERKORP_CD44_DN 22 0.057 0.504 0.05
CROMER_HYPOPHARYNGEAL_MET_VS_NON_DN 72 0.11 0.178 0.05
RUTELLA_HEPATGFSNDCS_UP 144 0.058 0.136 0.045
METHOTREXATE_PROBCELL_DN 11 0.102 0.132 0.033
GENOTOXINS_4HRS_DISCR 33 0.194 0.121 0.03
HTERT_UP 57 0.083 0.089 0.036
METHOTREXATE_PROBCELL_UP 14 0.147 0.111 0.046
CAMPTOTHECIN_PROBCELL_UP 17 0.085 0.159 0.038
UV_UNIQUE_FIBRO_UP 20 0.058 0.343 0.014
CITED1_KO_HET_DN 29 0.097 0.157 0.012
HEATSHOCK_YOUNG_UP 11 0.113 0.268 0.042
HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM 35 0.148 0.075 0.044
HSA00052_GALACTOSE_METABOLISM 27 0.053 0.277 0.044
HSA00521_STREPTOMYCIN_BIOSYNTHESIS 10 0.099 0.124 0.026
HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 83 0.106 0.25 0.049
HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 218 0.103 0.116 0.044
HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS 34 0.124 0.082 0.041