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Table 2 The inhibitory activity profiles of curcumin analogs on MCF7 and SKBR3 cells

From: Computational analyses of curcuminoid analogs against kinase domain of HER2

  SKBR3 MCF7   SKBR3 MCF7
AS-KTC IC50 IC50 AS-KTC IC50 IC50
  (μM) (μM)   (μM) (μM)
001 8.3 ± 0.6 41.9 ± 12.3 013 > 100 > 100
002 13.0 ± 1.8 44.4 ± 10.8 014 10.8 ± 5.5 9.9 ± 3.5
003 24.9 ± 2.3 81.6 ± 26.0 015 30.9 ± 4.5 15.4 ± 3.8
004 > 100 79.4 ± 9.8 016 42.6 ± 5.5 33.8 ± 5.8
005 > 100 > 100 017 21.3 ± 3.8 14.3 ± 1.9
006 15.4 ± 3.9 > 100 018 33.8 ± 7.2 22.4 ± 7.7
007 7.9 ± 2.5 17.5 ± 4.5 019 > 100 38.9 ± 9.1
008 7.9 ± 2.5 36.7 ± 5.8 020 25 ± 5.5 44.1 ± 9.0
009 8.2 ± 0.4 22.1 ± 0.1 021 16.9 ± 3.4 > 100
010 > 100 > 100 022 > 100 > 100
011 > 100 > 100 023 > 100 24.3 ± 8.7
012 9.9 ± 1.0 14.3 ± 1.6 024 > 100 > 100