Table 2 DNA SMART Cline scores
From: ReformAlign: improved multiple sequence alignments using a profile-based meta-alignment approach
APSI [25%-90%] (N = 264) | |||||||
|---|---|---|---|---|---|---|---|
Aligner | Initial (I) | Reformed (R) | Avg. Dif. (R-I) | p-value | R > I | R = I | R < I |
ClustalW | 59.55% | 67.06% | 7.51% | p < 0.001*** | 95.08% | 0.76% | 4.17% |
ClustalO | 70.94% | 74.25% | 3.31% | p < 0.001*** | 74.24% | 3.79% | 21.97% |
Kalign | 68.37% | 72.37% | 4.00% | p < 0.001*** | 87.50% | 3.41% | 9.09% |
Mafft (FFTnsi) | 71.93% | 74.81% | 2.88% | p < 0.001*** | 60.98% | 3.79% | 35.23% |
Mafft (Linsi) | 79.70% | 78.26% | −1.44% | p < 0.001*** | 33.71% | 7.20% | 59.09% |
Muscle | 69.51% | 72.52% | 3.01% | p < 0.001*** | 70.08% | 3.79% | 26.14% |
DialignTX | 60.82% | 70.13% | 9.31% | p < 0.001*** | 87.50% | 1.52% | 10.98% |
GramAlign | 66.96% | 70.11% | 3.15% | p < 0.001*** | 74.62% | 4.17% | 21.21% |
ProbCons | 73.68% | 73.90% | 0.22% | p = 0.099 | 54.55% | 3.41% | 42.05% |
PicXAA | 75.64% | 73.85% | −1.79% | p < 0.001*** | 28.03% | 3.03% | 68.94% |