Equivalent input produces different output in the UniFrac significance test

BMC Bioinformatics

Table 2 Weighted UniFrac p-values on compact form of lake sediment data

Sample	A2	B1	B2	C1	C2
A1	0.03	0.05	0.02	0.13	0.22
A2		0.03	0.05	0.15	0.26
B1			0.06	0.49	0.44
B2				0.32	0.55
C1					0.48

Weighted UniFrac uncorrected p-values between six samples of metagenomic lake sediment data. As samples A1 and A2 are from the same lake, we would expect them to be similar, but the low p-value here indicates that there is a much higher probability that they are significantly different than, say, A1 and C2.

ISSN: 1471-2105