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Table 2 Average (50 replicates) execution time (standard deviation) of simulating 1-Mb sequence data with a pre-specified number of recombination hotspots (mm:ss)*

From: Critical assessment of coalescent simulators in modeling recombination hotspots in genomic sequences

Number of hotspots

N

ms

msHOT

MaCS

Simcoal2*

Fastsimcoal

0

100

0:01 (2×10-3)

0:02 (0:01)

0:01 (0:00)

1:51 (0:03)

<0:01 (4×10-4)

500

0:01 (2×10-3)

0:04 (0:01)

0:06 (0:01)

2:19 (0:04)

0:03 (3×10-3)

1,000

0:02 (5×10-3)

0:06 (0:01)

0:23 (0:02)

2:34 (0:08)

0:08 (0:01)

10,000

---

---

5:42 (0:13)

3:51 (0:07)

2:18 (0:03)

2

100

---

1:28 (0:02)

0:03 (0:01)

1:51 (0:06)

<0:01 (3×10-4)

500

---

1:43 (0:05)

0:10 (0:01)

2:45 (0:08)

0:03 (0:01)

1,000

---

1:51 (0:05)

0:25 (0:03)

2:50 (0:09)

0:08 (0:01)

10,000

---

2:39 (0:07)

5:43 (0:10)

4:27 (0:11)

2:22 (0:03)

5

100

---

2:48 (0:05)

0:02 (0:01)

2:30 (0:06)

<0:01 (9×10-4)

500

---

3:14 (0:07)

0:10 (0:02)

2:41 (0:05)

0:03 (5×10-3)

1,000

---

3:33 (0:06)

0:23 (0:02)

3:24 (0:07)

0:09 (0:02)

 

10,000

---

4:27 (0:11)

5:36 (0:15)

4:10 (0:09)

2:32 (0:05)

  1. * “N” denotes sample size (i.e., the number of DNA sequences) for each replicate. “---” denotes a segmentation fault (e.g., ms could not simulate sequence data with recombination hotspots).