Predicting disease associations via biological network analysis

BMC Bioinformatics

Table 5 List of the top 10 diseases associated with DM

Rank	Code	Disease name	Reference
1	239	Neoplasms of unspecified	PMID: 23639840
		nature
2	155	Malignant neoplasm of liver	GWAS
		and intrahepatic bile ducts
3	710	Diffuse diseases of connective	GWAS
		tissue
4	714	Rheumatoid arthritis and other	GWAS
		inflammatory polyarthropathies
5	256	Ovarian dysfunction	ICD-9, GWAS
5	278	Overweight, obesity and	ICD-9, comorbidity,
		other hyperalimentation	GWAS
7	401	Essential hypertension	Comorbidity
8	295	Schizophrenic disorders	PMID: 17474808
9	282	Hereditary hemolytic anemias	GWAS
10	289	Other diseases of blood and	PMID: 11727971
		blood-forming organs

The top 10 diseases associated with DM were inferred using the topology-based similarity measure and FunDO as the source of disease-gene associations. Only diseases annotated in all four disease-gene association datasets are listed in the table. For a disease associated with DM according to ICD-9, comorbidity or GWAS, we added the supported evidence to the reference (the last column). The remaining disease associations were validated via mining the literature on PubMed (http://www.ncbi.nlm.nih.gov/pubmed), and for each disease only one reference (shown by PubMed ID) was listed in the table due to space limitation.

ISSN: 1471-2105