Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions

Table 3 Cyclic peptides derived from EGF-domain containing proteins and tested for EGF activation/inhibition

No.	Cyclic peptide sequence	Human parent protein
1	CVVGYIGERC	EGF, Epidermal Growth Factor*
2	CHSGYVGARC	TGFA, Transforming Growth
		Factor Alpha*
3	CQQEYFGERC	AREG, Amphiregulin*
4	CDEGYIGARC	BTC, Betacellulin*
5	CHPGYHGERC	HBEGF, Heparin-binding EGF-like
		growth factor*
6	CEVGYTGVRC	EREG, Epiregulin*
7	CQPGFTGARC	NRG1, Neuregulin-1**
8	CPNGFFGQRC	NRG2, Neuregulin-2**
9	CKEGYQGVRC	NRG3, Neuregulin-3**
10	CVENYTGARC	NRG4, Neuregulin-4**
11	CAQECVHGRC	PEAR1, Platelet endothelial
		aggregation receptor 1
12	CTRTGYSGPNC	PTGS1, Prostaglandin G/H
		synthase 1
13	CDPGFSGLKC	SELE, E-selectin
14	CLPAFEGRNC	F7, Coagulation factor VII
15	CDSDWTGYYC	ITGB3, Integrin Beta 3

^*Denotes growth factors known to directly activate the EGF receptor. ^**Denotes growth factors known to directly activate members of the ErbB receptor family other than EGFR/ErbB1.

ISSN: 1471-2105