Schematic representation of the network enrichment analysis applied to detection of driver mutations. A, total quantification of inter-relations between somatic point mutations (PM) in one genome. B, test of a single point mutation for being related to all other PMs (1point-vs-MGS). C, test of a copy number alteration (CNA) against all PMs in the same genome (1CNA-vs-MGS). D, test of either a CNA or PM against a known cancer pathway (CP), irrespective of genome (1-vs-CPW). E, overview of the algorithm. The analyses at B, C, and D were summarized into a single combined p-value for each gene copy number change (yellow) and point mutation (red).