Figure 1From: Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysisSchematic representation of the network enrichment analysis applied to detection of driver mutations. A, total quantification of inter-relations between somatic point mutations (PM) in one genome. B, test of a single point mutation for being related to all other PMs (1point-vs-MGS). C, test of a copy number alteration (CNA) against all PMs in the same genome (1CNA-vs-MGS). D, test of either a CNA or PM against a known cancer pathway (CP), irrespective of genome (1-vs-CPW). E, overview of the algorithm. The analyses at B, C, and D were summarized into a single combined p-value for each gene copy number change (yellow) and point mutation (red).Back to article page