Figure 3

Network enrichment analysis of point mutations in genome TCGA-02-0014. The likelihood that one of the 34 mutated genes in the genome (indicated by red and black nodes) was determined either based on their linkage to the set of other 33 point mutations (black crosses), or in the context of known cancer pathways (red circles), or by both criteria (red crosses). Mutations that did not reveal any functional involvement are indicated by black circles. Linkage to cancer pathways is exemplified by the relationship between TGFBR2 and the genes of the KEGG05214 glioma pathway (green circles). Other relationships of this type are not shown.