Driver analysis over extended chromosomal regions. All the components of NEA were run over copy-number altered regions of chromosome 7 in the ovarian cancer. The grey areas mask the chromosomal regions omitted from this plot, so that only four selected regions are shown. Multi-colored bars in the lower plot indicate the copy numbers in individual OV genomes relative to the reference diploid genome (dotted red line). Grey lines indicate the 10th, 25th, 50th, 75th, and 90th percentiles of copy number in the OV cohort. The upper plot shows the prioritization of genes based on the–log10 of their combined p-values: genes with higher positions are more highly prioritized. Genes found to be highly significant in the 1-vs-CPW analysis are highlighted in red, those highly significant in the 1CNA-vs-MGS analysis are marked with a black asterisk, and red asterisks indicate genes highly significant in both analyses. Gene symbols in brackets indicate point mutations that co-occurred with the driver CNAs. A complete version of this figure can be found in the Additional file 2 and Additional file 3: GBM.CNA_drivers_along_chromosomes.pdf and OV.CNA_drivers_along_chromosomes.pdf.