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Table 1 Results of mrSNP on 16 experimentally validated disease-associated SNPs described in [[20]]

From: mrSNP: Software to detect SNP effects on microRNA binding

SNP miRNA Chr Position Alleles Success Explanation
rs1063320 hsa-miR-152 6 29798749 C G Binds one of the sequences with 7 consecutive matches. SNP breaks the match on the 7th position, min. match critera is not satisfied.
rs1063320 hsa-miR-148a 6 29798749 C G Binds one of the sequences with 8 consecutive matches. SNP breaks the match on the 7th position, min. match critera is not satisfied.
rs1063320 hsa-miR-148b 6 29798749 C G Binds one of the sequences with 7 consecutive matches. SNP breaks the match on the 7th position, min. match critera is not satisfied.
rs3134615 hsa-miR-1827 1 40362066 A C Binds one of the sequences with 8 consecutive matches. SNP breaks the match on the 6th position, min. match critera is not satisfied.
rs4245739 hsa-miR-191 1 204518842 A C Binds one of the sequences with 8 consecutive matches. SNP breaks the match on the 5th position, min. match critera is not satisfied.
rs56109847 hsa-miR-510 3 183824557 A G Binds one of the sequences with 8 consecutive matches. SNP breaks the match on 5th position, min. match critera is not satisfied.
rs5186 has-miR-155 3 148459988 A C Binds one of the sequences with 7 consecutive matches. SNP breaks the match on 4th position, min. match critera is not satisfied.
rs1434536 hsa-miR-125b 4 96075965 T C Binds one of the sequences with 8 consecutive matches. SNP introduces a GU wobble on 8th position (7th of seed), the binding energy is below the cut off.
rs193302862 hsa-miR-24 13 84452863 C T Binds one of the sequences with 9 consecutive matches. SNP introduces a GU wobble on 8th position (7th of the seed), the binding energy is lower than cut off.
rs8126 hsa-miR-184 14 103603569 C T Binds one of the sequences with 7 consecutive matches. SNP introduces a GU wobble on 6th position (7mer with a GU wobble), the binding energy is below the cut off.
rs12720208 has-miR-433 8 16850399 G A Binds one of the sequences with 7 consecutive matches. SNP introduces a GU wobble on 6th position, the binding energy is lower than cut off.
rs13212041 hsa-miR-96 6 78171124 C T × SNP is not in 3’UTR
rs2735383 hsa-miR-629 8 90947269 C G × miRNA is predicted not to bind either of the sequences. There exists a mistmatch on the 4th position regardless of the SNP. SNP further breaks the match on 3rd position.
rs34764978 has-miR-24 5 79924683 A G × miRNA is predicted not to bind either of the sequences. Both have only 6 matches with GU wobble.
rs9341070 has-miR-206 6 152420197 C T × miRNA is predicted not to bind either of the sequences. min. match criteria cannot be satisfied in both
rs67384697 hsa-miR-148a 6 31236683 C - × miRNA is predicted to bind both of the sequences. SNP reduces 11 consecutive match to 9.
  1. mrSNP captures 11 disease-associated SNPs out of 16 SNPs (69%).