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Figure 1 | BMC Bioinformatics

Figure 1

From: Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method

Figure 1

THIPA (Thick Patch Analysis): An Automated Epitope Network Prediction Pipeline. A) Patch vector files are generated using structural, genotypic, and phenotypic data. Subsequently, patches are analyzed by multiple machine learning and statistical methods, and patches identified as significantly associated with neutralization by all models are selected. B) Significant patches are then aligned by position to identify residue clusters that are frequently recognized as significant. The overlapping residues identified more frequently than average are reported as predicted epitope networks and are modeled into the 3D structure (highlighted in this cartoon example in green).

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BMC Bioinformatics

ISSN: 1471-2105

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