Figure 2
From: ShatterProof: operational detection and quantification of chromothripsis
Suspect region identification and score calculation. Once ShatterProof has parsed all input data, a sliding window analysis identifies genomic regions which are heavily mutated. Note that the window size is user definable. ShatterProof then produces a chromothripsis score for each of these regions, by analyzing all SV data corresponding to it. The analysis produces hallmark scores which represent how significantly the region exhibits each hallmark,which are then scaled by their respective MCA weighting and summed to produce a chromothripsis score.