Separation of successfully versus failed validations of selected hits. The cut-off for the top 50 hits are indicated by dashed lines. (A-C) Position of validations in the P-value A and B space (log-scale). (D-F) Distribution of all the combined P-values (A and B combined according to Brown’s method) with positions of validated hits. Experimentally validated true positives are indicated in green, false positive hits in red.