Figure 1

Kernel density and scatter plot of all variants. Gaussian kernel densities with associated scatter plots indicating the frequency of the cells carrying all acquired mutations for the three samples are listed. A denotes the Presentation sample, B Relapse #1 and C Relapse #2. The peaks in the kernel density plot may indicate dominant clones and any subclones. The x-axis for both kernel density and scatter plots are VAF. The y-axis in each density plot is density (adjusted by copy number), and the y-axis in each scatter plot is CN * Depth. Key genes are annotated.