Variant dynamics and clonal evolution. The variant dynamics and clonal evolution of key genes across the Presentation (red), Relapse #1 (green) and Relapse #2 (blue) samples are illustrated. Information regarding the year each sample was obtained, total number of mutations (N), computed Shannon Diversity Index (SDI), and the number of key genes (KG) are provided for each sample. Key genes identified within each sample are listed. An arc from a gene symbol into another sample indicates the survival of the mutation through the selection event (definitive therapy). "Dead Pools" list key genes and/or passengers that do not survive.