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Table 1 The Order versus Disorder Prediction Performances of 19 Hydropathy Scales.

From: Improving protein order-disorder classification using charge-hydropathy plots

Scales Sens Spec Bal. Acc AUC
Guy 0.70 ± 0.16 0.97 ± 0.02 0.84 ± 0.09 0.90 ± 0.06
Miyazawa 0.70 ± 0.15 0.96 ± 0.02 0.83 ± 0.09 0.90 ± 0.11
Manavalan 0.70 ± 0.15 0.96 ± 0.03 0.83 ± 0.09 0.90 ± 0.07
Sweet 0.69 ± 0.14 0.97 ± 0.02 0.83 ± 0.09 0.91 ± 0.07
Fauchere 0.68 ± 0.13 0.97 ± 0.02 0.83 ± 0.08 0.88 ± 0.07
Rose 0.67 ± 0.17 0.97 ± 0.02 0.82 ± 0.09 0.91 ± 0.06
Black 0.64 ± 0.09 0.97 ± 0.02 0.81 ± 0.06 0.88 ± 0.06
Woods 0.61 ± 0.15 0.97 ± 0.03 0.79 ± 0.09 0.88 ± 0.06
Breese 0.64 ± 0.12 0.95 ± 0.04 0.80 ± 0.08 0.87 ± 0.08
Leo 0.61 ± 0.12 0.96 ± 0.03 0.79 ± 0.08 0.86 ± 0.08
Kyte-Doolittle 0.61 ± 0.16 0.96 ± 0.03 0.79 ± 0.09 0.87 ± 0.10
Roseman 0.56 ± 0.16 0.96 ± 0.02 0.76 ± 0.09 0.86 ± 0.08
Chothia 0.55 ± 0.13 0.96 ± 0.03 0.76 ± 0.08 0.88 ± 0.05
Argos 0.54 ± 0.10 0.97 ± 0.03 0.76 ± 0.06 0.85 ± 0.06
Janin 0.52 ± 0.16 0.96 ± 0.02 0.74 ± 0.09 0.86 ± 0.06
Tanford 0.49 ± 0.14 0.96 ± 0.03 0.73 ± 0.08 0.86 ± 0.09
Eisenberg 0.48 ± 0.19 0.96 ± 0.03 0.72 ± 0.11 0.85 ± 0.05
Welling 0.40 ± 0.14 0.97 ± 0.03 0.69 ± 0.09 0.79 ± 0.07
Wolfenden 0.36 ± 0.11 0.97 ± 0.02 0.67 ± 0.07 0.79 ± 0.06
  1. For equations and explanations, see the Methods section at the end of this manuscript:
  2. Sens: Sensitivity
  3. Spec: Specificity
  4. Bal. Acc: Balanced accuracy (average of sensitivity and specificity)
  5. AUC: Area under the curve