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Table 2 Summary of 50 drugs implicated by ALF-Topic without apparent ALF evidence in the LiverTox database.

From: Mining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case study

Drug name 1st topic 2nd topic 3rd topic
  Topic ID Prob. Topic ID Prob. Topic ID Prob.
Atovaquone 37 6.2E-01 14 3.8E-01 40 5.9E-05
Buprenorphine 22 4.1E-01 37 3.1E-01 31 2.5E-01
Clarithromycin 37 5.3E-01 17 2.6E-01 3 1.8E-01
Diflunisal 37 3.6E-01 38 2.6E-01 29 2.2E-01
Flecainide 37 4.3E-01 18 2.7E-01 30 2.1E-01
Infliximab 37 5.4E-01 14 3.6E-01 39 9.6E-02
Methimazole 37 6.1E-01 7 3.9E-01 40 4.4E-05
Minocycline 37 8.9E-01 35 1.1E-01 40 6.9E-05
Nabumetone 38 4.2E-01 36 4.2E-01 37 1.5E-01
Proguanil 37 5.8E-01 14 4.2E-01 40 4.0E-05
Salsalate 38 6.4E-01 37 1.9E-01 30 1.7E-01
Ticlopidine 37 4.5E-01 31 2.9E-01 7 2.5E-01
Topiramate 35 4.9E-01 37 3.5E-01 5 1.7E-01
Chlorzoxazone* 37 6.4E-01 17 2.2E-01 20 1.0E-01
Cocaine* 29 4.7E-01 37 2.4E-01 23 1.7E-01
Chlorpromazine* 13 7.0E-01 21 1.9E-01 37 1.1E-01
Greater celandine* 37 8.2E-01 20 9.8E-02 34 5.9E-02
Hydralazine* 37 6.7E-01 17 3.0E-01 35 3.4E-02
Jin bu huan* 37 5.7E-01 27 2.6E-01 14 1.7E-01
Shouwupian* 37 9.8E-01 27 2.1E-02 40 5.2E-05
Colchicineठ33 4.0E-01 37 2.5E-01 9 1.9E-01
Fenofibrateठ37 8.7E-01 33 1.3E-01 40 2.7E-05
Mebendazoleठ5 4.6E-01 2 2.5E-01 37 2.3E-01
Metforminठ37 6.2E-01 10 3.5E-01 32 2.8E-02
Nifedipineठ37 5.9E-01 14 2.2E-01 21 1.7E-01
Verapamilठ37 5.9E-01 21 3.6E-01 9 5.1E-02
Acebutolol 37 5.4E-01 5 4.6E-01 40 3.6E-05
Adefovir 26 5.9E-01 37 3.1E-01 30 9.6E-02
Alfuzosin 21 6.0E-01 37 2.2E-01 30 1.8E-01
Ceftriaxone 37 5.3E-01 33 3.3E-01 7 8.0E-02
Gold salts 37 7.0E-01 39 1.9E-01 4 1.1E-01
Linezolid 6 3.9E-01 36 2.6E-01 37 2.0E-01
Montelukast 31 4.3E-01 37 3.4E-01 5 2.1E-01
Olanzapine 37 5.9E-01 13 1.8E-01 19 1.7E-01
Orphenadrine 29 5.8E-01 37 3.7E-01 11 5.2E-02
Oxacillin 37 5.8E-01 4 3.7E-01 12 4.5E-02
Phenelzine 31 6.2E-01 37 3.6E-01 1 1.9E-02
Risperidone 37 6.4E-01 13 3.2E-01 18 2.9E-02
Sotalol 32 4.7E-01 37 4.3E-01 7 1.0E-01
Thioridazine 13 8.4E-01 37 1.6E-01 40 4.0E-05
Ticarcillin/clavulanate 37 4.5E-01 4 3.2E-01 3 2.3E-01
Trisalicylate 38 5.4E-01 37 4.6E-01 40 4.1E-05
Clofibrate 37 4.0E-01 31 3.4E-01 33 2.6E-01
Methocarbamol 37 3.5E-01 25 3.3E-01 38 2.9E-01
Pentamidine 37 7.7E-01 29 2.3E-01 40 5.7E-05
Reserpine 37 5.3E-01 36 3.2E-01 9 9.3E-02
Aloe Vera 37 6.1E-01 9 2.8E-01 36 1.1E-01
Ba Jiao Lian 25 5.9E-01 37 4.1E-01 40 6.4E-05
Chi R Yun 25 3.2E-01 37 2.7E-01 11 2.4E-01
Shosaikoto/daisaikoto 37 7.6E-01 23 2.4E-01 40 3.8E-05
  1. 26% (13/50) drugs confirmed by safety concerns about ALF in the FDA-approved drug labels.
  2. *14% (7/50) drugs confirmed by the literature with justified ALF causality.
  3. 44% (22/50) drugs confirmed by ALF case reports in the FAERS.
  4. §These 6 drugs were predicted as ALF positive drugs by the in vitro experiment.
  5. Topic-37 is the ALF-Topic.
  6. Topic ID: serial number of topics in topic model.
  7. Prob.: conditional probability of each topic to a drug.
  8. Topic model ranks topics in accordance to their probability to each drug.