Figure 1
From: On the expansion of “dangerous” gene families in vertebrates
Quantitative Mediation analysis of direct versus indirect effects of deleterious mutations and dosage balance on the retention of human ohnologs using (A) all human protein coding genes (20,506) or (B) human protein coding genes without SSD nor CNV (8,215). The thickness of the arrows outlines the relative importance of the corresponding direct or indirect effects. Dir.< 0 or Ind.<0 corresponds to an anticorrelated direct or indirect effect, respectively. Gene prone to deleterious mutations and/or to dosage balance (including haploinsufficient genes and genes involved in multiprotein complexes) are taken from [3].