Table 1 Places of the model [4]

p1

alpha-factor

pheromone released by an MATα cell in the surroundings

p2

Ste2_receptor

mating pheromone receptor of the modelled MATa cell

p3

receptor_factor_complex

complex consisting of the α factor and the Ste2 receptor

p4

receptor_complex

the above named complex is activated by a conformation change

p5

trimer_bound_to_receptor

heterotrimeric G protein, which is coupled to the Ste2 receptor

p6

G_alpha_GTP

dissociated Gα subunit (exchange of GDP to GTP in this monomer)

p7

G_beta_gamma_dimer

G-protein G _βγ subunits in a dimer form

p8

Cdc24

Cdc24, i.e., guanine nucleotide exchange factor of Cdc42

p9

Cdc42(at pm)

Cdc42 located at the plasma membrane

p10

Ste20

protein kinase Ste20

p11

Ste5(scaffold)

Ste5, acting as a scaffold protein

p12

Ste5/Ste11

protein complex consisting of ste7 and Fus3

p13

Fus3

MAP kinase Fus3

p14

Ste7/Fus3

protein complex consisting of Ste7 and Fus3

p15

MAPK_complex

MAPK complex consisting of Ste5,Ste11,Ste7 and Fus3

p16

Ste20_at_pm

Ste20 located at the plasma membrane, i.e., near the MAPK complex

p17

complex2

as complex1, but Ste11 is activated additionally

p18

complex3

as complex2, but Ste7 is activated additionally

p19

complex4

as complex3, but Fus3 is activated additionally

p20

Fus3PP

dissociated Fus3 in the activated form

p21

complex_without_Fus3

as complex4, but without Fus3

p22

repr_complex

complex containing Ste12 repressed by Fus3 or Kss1 and Dig1/Dig2

p23

Dig1/Dig2

Ste12 inhibitors, i.e., cofactors for the repression

P24

free_Ste12

Ste12 released out of the repression complex

p25

Ste12

activated transcription factor Ste12

p26

Msg5

phosphatase Msg5 being able to deactivate Fus3 or Kss1

p27

Fus3_dephos

deactivated Fus3

p28

other_genes

pheromone regulated genes encoding mating related cell responses

p29

Bar1_in_nucleus

synthesised protease Bar1 located in the nucleus

p30

Bar1

Bar1 secreted in the cell environment

p31

inactive_Far1

synthesised Far1 located in the nucleus in an inactive form

p32

Far1

Far1 activated by phosphorylation

p33

Far1_in_cytosol

active Far1 located in the cytosol

p34

Sst2_in_nucleus

synthesised Sst2 located in the nucleus in an inactive form

p35

phos_Sst2

Sst2 activated by phosphorylation

p36

Sst2

active Sst2 located in the cytosol

p37

inactive_component

complex labelled for degradation by phosphorylation

p38

phos_Kss1

MAP kinase Kss1 activated by phosphorylation

p39

unphos_Kss1

inactive Kss1

p40

Akr1

protein Akr1 located at plasma membrane

p41

Yck1/Yck2_at_pm

kinases Yck1/Yck2 being able to label the Ste2 for degradation

p42

inactive_receptor

receptor labelled for ubiquitination and endocytosis

p43

Ste11

protein kinase Ste11

p44

Ste50

protein kinase Ste50

p45

Bem1

protein Bem1

p46

Ste7

protein kinase Ste7