Table 1 The four scales of ENISI models, their spatial and temporal properties, as well as modeling technologies and tools for each scale.
Scale | Example scenarios | Spatial (m) | Time (s) | Technology | Tool |
|---|---|---|---|---|---|
Intra-cellular | Signaling pathways | Nano | Nano | ODE | COPASI |
Cellular | Cell movement and subtypes | Milli | Tens | ABM | ENISI |
Inter-cellular | Cytokine diffusion | Milli | Tens | PDE | ValueLayer |
Tissue | Inflammation and lesions | Centi | Thousands | Projections | ENISI |