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Figure 5 | BMC Bioinformatics

Figure 5

From: Global multiple protein-protein interaction network alignment by combining pairwise network alignments

Figure 5

SMAL allows creation of MNAs based on pairwise alignment algorithms that are superior to any existing native MNA algorithm for a given measure. Alignments are shown for six species with the human PPIN as the scaffold. The same overall picture of SMAL based on PINALOG PNAs holds for 4, 5, 6, 7, 8-species MNAs as well as for any choice of the scaffold. The y-axis shows the fraction of all aligned nodes that are homologous. Higher values represent a biologically more relevant alignment. Algorithms are abbreviated: IR - IsoRankN, SM - SMETANA, PI - PINALOG, NT - NETAL. Since PINALOG and NETAL do not have native MNA implementations, there are no native data to report.

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BMC Bioinformatics

ISSN: 1471-2105

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