Analysis of genomic rearrangements by using the Burrows-Wheeler transform of short-read data

BMC Bioinformatics

Table 1 Sensitivity of breakpoint detection at 40-times coverage.

Data set	Cancer purity	Number of breakpoints		Sensitivity
		Predicted	Detected
sim10	100%	457	455	95%
sim05	50%	455	452	94%
sim03	30%	456	446	93%
sim02	20%	454	433	90%
sim01	10%	445	356	74%

Simulation data with known artificial rearrangements are employed for evaluation of the proposed method. The third and fourth columns indicate the number of predicted breakpoint regions and the number of detected breakpoints, respectively. The last column is the ratio of the fourth column to all (480) breakpoints.

ISSN: 1471-2105