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Table 4 Binding cavity size and area

From: Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease

WILD
CAVITY 0 ns 5 ns 10 ns 15 ns 20 ns 1OHR
VOLUME (Å 3 ) 1186.1 976.3 990.3 113.3 1097.3 1186.1
AREA (Å 2 ) 705.9 612.3 734.6 739.645 645.3 705.9
DBM
CAVITY 0 ns 5 ns 10 ns 15 ns 20 ns Representative
VOLUME (Å 3 ) 1156.0 790.6 1271.5 1403.2 1024.1 1375.5
AREA (Å 2 ) 686.2 505.4 697.7 771.6 757.0 732.1
TPM
CAVITY 0 ns 5 ns 10 ns 15 ns 20 ns Representative
VOLUME (Å 3 ) 1156.0 1257.8 938.3 820.2 801.2 1042.5
AREA (Å 2 ) 686.2 753.9 554.8 572.9 498.5 634.3