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Figure 1 | BMC Bioinformatics

Figure 1

From: An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in Acute Myeloid Leukemia

Figure 1

Hierarchical clustering by means of the scenarios, and Kaplan-Meier curves. Leukemia related WNT signaling genes (13 genes, 17 refseqs) are classified in the mutually exclusive scenarios, and (A) hierarchically clustered using hamming distance and complete linkage. The dendrogram is cut at the top level which resulted in eight distinctive clusters. Significantly enriched scenarios, cytogenetical characteristics and molecular abnormalities are described. (B) Patients in cluster 1, and cluster 5 show significant unfavourable outcome in overall survival, and (C) event-free survival in a univariate analysis (log-rank test), and after correcting for known prognostic markers in a multivariate analysis. The horizontal and vertical bar plots illustrates the marginal collective distribution of the scenarios among the genes, and samples respectively.

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BMC Bioinformatics

ISSN: 1471-2105

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