|
Variables
|
P-value
|
HR
|
95% CI-low
|
CI-high
|
|---|
|
Overall survival
| | | | |
|
LEF1 (scenario 8)
|
0.00642
|
1.58
|
1.14
|
2.19
|
|
CEBPAdmα
|
0.00214
|
0.33
|
0.16
|
0.67
|
|
FLT3ITD β
|
0.00025
|
1.77
|
1.30
|
2.40
|
|
NPM1+β
|
0.00005
|
0.51
|
0.37
|
0.71
|
|
WBC countδ, × 109/L
|
0.00886
|
1.00
|
1.00
|
1.00
|
|
Age$
|
0.00005
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
SFRP2 (scenario 2, 8)
|
0.00091
|
2.00
|
1.33
|
3.00
|
|
CEBPAdmα
|
0.00160
|
0.32
|
0.16
|
0.65
|
|
FLT3ITD β
|
0.00007
|
1.87
|
1.37
|
2.55
|
|
NPM1+ β
|
0.00006
|
0.52
|
0.38
|
0.71
|
|
WBC countδ, × 109/L
|
0.00470
|
1.00
|
1.00
|
1.01
|
|
Age$
|
0.00007
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
RUNX1 (scenario 3)
|
0.03768
|
1.38
|
1.02
|
1.88
|
|
CEBPAdmα
|
0.00308
|
0.34
|
0.17
|
0.69
|
|
FLT3ITD β
|
0.00023
|
1.78
|
1.31
|
2.41
|
|
NPM1+ β
|
0.00004
|
0.51
|
0.37
|
0.71
|
|
WBC countδ, × 109/L
|
0.01106
|
1.00
|
1.00
|
1.00
|
|
Age$
|
0.00001
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
PSMD2 (scenario 5, 6)
|
0.00220
|
0.60
|
0.43
|
0.83
|
|
CEBPAdmα
|
0.00130
|
0.31
|
0.15
|
0.63
|
|
FLT3ITD β
|
0.00006
|
1.87
|
1.38
|
2.55
|
|
NPM1+ β
|
0.00160
|
0.59
|
0.42
|
0.82
|
|
WBC countδ, × 109/L
|
0.00270
|
1.00
|
1.00
|
1.01
|
|
Age$
|
0.00009
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
XPNPEP (scenario 1)
|
0.00200
|
1.56
|
1.18
|
2.07
|
|
CEBPAdmα
|
0.00084
|
0.30
|
0.15
|
0.60
|
|
FLT3ITD β
|
0.00130
|
1.66
|
1.22
|
2.26
|
|
NPM1+ β
|
0.00020
|
0.55
|
0.40
|
0.75
|
|
WBC countδ, × 109/L
|
0.01190
|
1.00
|
1.00
|
1.00
|
|
Age$
|
0.00015
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
PPARD (scenario 4, 6)
|
0.00063
|
0.52
|
0.36
|
0.76
|
|
CEBPAdmα
|
0.00075
|
0.29
|
0.14
|
0.60
|
|
FLT3ITD β
|
0.00011
|
1.83
|
1.35
|
2.48
|
|
NPM1+ β
|
0.00084
|
0.57
|
0.41
|
0.79
|
|
WBC countδ, × 109/L
|
0.00360
|
1.00
|
1.00
|
1.01
|
|
Age$
|
0.00001
|
1.02
|
1.01
|
1.03
|
|
Overall survival
| | | | |
|
AXIN2 (scenario 8)
|
0.0038
|
1.79
|
1.21
|
2.66
|
|
CEBPAdmα
|
0.0009
|
0.30
|
0.15
|
0.61
|
|
FLT3ITD β
|
0.0003
|
1.77
|
1.30
|
2.40
|
|
NPM1+ β
|
0.0003
|
0.55
|
0.40
|
0.76
|
|
WBC countδ, × 109/L
|
0.0100
|
1.00
|
1.00
|
1.00
|
|
Age$
|
0.00004
|
1.02
|
1.01
|
1.03
|
- Cox proportional hazard model for multivariable analyses of prognostic markers for overall survival. Analyses included 344 AML patients. Abbreviations: HR, hazard ratio; CI, confidence interval; α CEBPAdouble−mutation status versus CEBPAwt, β FLT3ITD versus no FLT3ITD mutation, β NPM1mutant versus NPM1wt, δ WBC count higher than 20 × 109/L versus lower than 20 × 109/L, $ Age is used as continuous variable.
