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Table 1 Multivariate analysis for the identified prognostic genes for overall survival (OS).

From: An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in Acute Myeloid Leukemia

Variables P-value HR 95% CI-low CI-high
Overall survival     
   LEF1 (scenario 8) 0.00642 1.58 1.14 2.19
   CEBPAdmα 0.00214 0.33 0.16 0.67
   FLT3ITD β 0.00025 1.77 1.30 2.40
   NPM1+β 0.00005 0.51 0.37 0.71
   WBC countδ, × 109/L 0.00886 1.00 1.00 1.00
   Age$ 0.00005 1.02 1.01 1.03
Overall survival     
   SFRP2 (scenario 2, 8) 0.00091 2.00 1.33 3.00
   CEBPAdmα 0.00160 0.32 0.16 0.65
   FLT3ITD β 0.00007 1.87 1.37 2.55
   NPM1+ β 0.00006 0.52 0.38 0.71
   WBC countδ, × 109/L 0.00470 1.00 1.00 1.01
   Age$ 0.00007 1.02 1.01 1.03
Overall survival     
   RUNX1 (scenario 3) 0.03768 1.38 1.02 1.88
   CEBPAdmα 0.00308 0.34 0.17 0.69
   FLT3ITD β 0.00023 1.78 1.31 2.41
   NPM1+ β 0.00004 0.51 0.37 0.71
   WBC countδ, × 109/L 0.01106 1.00 1.00 1.00
   Age$ 0.00001 1.02 1.01 1.03
Overall survival     
   PSMD2 (scenario 5, 6) 0.00220 0.60 0.43 0.83
   CEBPAdmα 0.00130 0.31 0.15 0.63
   FLT3ITD β 0.00006 1.87 1.38 2.55
   NPM1+ β 0.00160 0.59 0.42 0.82
   WBC countδ, × 109/L 0.00270 1.00 1.00 1.01
   Age$ 0.00009 1.02 1.01 1.03
Overall survival     
   XPNPEP (scenario 1) 0.00200 1.56 1.18 2.07
   CEBPAdmα 0.00084 0.30 0.15 0.60
   FLT3ITD β 0.00130 1.66 1.22 2.26
   NPM1+ β 0.00020 0.55 0.40 0.75
   WBC countδ, × 109/L 0.01190 1.00 1.00 1.00
   Age$ 0.00015 1.02 1.01 1.03
Overall survival     
   PPARD (scenario 4, 6) 0.00063 0.52 0.36 0.76
   CEBPAdmα 0.00075 0.29 0.14 0.60
   FLT3ITD β 0.00011 1.83 1.35 2.48
   NPM1+ β 0.00084 0.57 0.41 0.79
   WBC countδ, × 109/L 0.00360 1.00 1.00 1.01
   Age$ 0.00001 1.02 1.01 1.03
Overall survival     
   AXIN2 (scenario 8) 0.0038 1.79 1.21 2.66
   CEBPAdmα 0.0009 0.30 0.15 0.61
   FLT3ITD β 0.0003 1.77 1.30 2.40
   NPM1+ β 0.0003 0.55 0.40 0.76
   WBC countδ, × 109/L 0.0100 1.00 1.00 1.00
   Age$ 0.00004 1.02 1.01 1.03
  1. Cox proportional hazard model for multivariable analyses of prognostic markers for overall survival. Analyses included 344 AML patients. Abbreviations: HR, hazard ratio; CI, confidence interval; α CEBPAdouble−mutation status versus CEBPAwt, β FLT3ITD versus no FLT3ITD mutation, β NPM1mutant versus NPM1wt, δ WBC count higher than 20 × 109/L versus lower than 20 × 109/L, $ Age is used as continuous variable.
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