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Table 1 Single Run Comparisons of OSLEM and EM:

From: Optimal Step Length EM Algorithm (OSLEM) for the estimation of haplotype frequency and its application in lipoprotein lipase genotyping

  

Number of Loops

 

CPU time

 

# SNPs

Precision

OSLEM

EM

OSLEM: EM

OSLEM

EM

OSLEM: EM

12

1e-9

305

621

0.49

0.45

0.80

0.56

13

1e-7

305

579

0.53

0.95

1.69

0.56

14

1e-7

183

343

0.53

0.78

1.62

0.48

15

1e-7

182

342

0.53

0.87

1.78

0.49

16

1e-9

523

1149

0.45

4.92

11.28

0.44

  1. EM = Expectation maximization algorithm, OSLEM = Optimal Step Length EM algorithm The unit for CPU time is millisecond. The precision is the sum of the absolute differences of the haplotype frequencies between two loops.