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Table 1 Kelch-repeat proteins of H. sapiens

From: Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

Architecture Domain organisation GenBank Accession Alternate name Amino Acids Chromosome localisation Reference
BTB/kelch       
  BTB/K5(C) NP_055666 KIAA0469 539 1p36.23 75
  BTB/K5(C) NP_006054 Sarcosin, KLP23, Krp1 606 + 2q31.1 76, 77
  BTB/K5(C) AAH10437   558 2q31.1 78
  BTB/K5(C) NP_115894 Tcell activation kelch-repeat protein 575 3p14 79
  BTB/K5(C) NP_689606 Sarcosynapsin 472 3p21.32  
  BTB/K5(C) NP_060114   412 3q27.3  
  BTB/K5(C) XP_291224 KIAA1489 623 7p14.3  
  BTB/K5(C) XP_063481 *   819 14q11.1  
  BTB/K5(C) XP_171687 *   458 $ 15q21.2  
  BTB/K6(C) NP_005888 IPP 584 1p32 80
  BTB/K6(C) NP_055273 Kelch motif-containing protein, KLX 609 1q24.1-24.3  
  BTB/K6(C) NP_006460 NS1-binding protein, Nd1 orthologue 642 1q25.1 81, 82
  BTB/K6(C) NP_067646 Kelch-like protein C3IP1 568 1q31.3  
  BTB/K6(C) BAB67814 KIAA1921 545 2p23.2 83
  BTB/K6(C) XP_292990   649 2q37.3  
  BTB/K6(C) XP_093813 *   585 3q21.3  
  BTB/K6(C) BAB93503   509 3p21.31  
  BTB/K6(C) NP_569713 KLHL6 610 3q27.3 84, 85
  BTB/K6(C) NP_057074 KLHL5, lymphocyte activation-associated protein 734 @ 4p15.1 86
  BTB/K6(C) NP_009177 Mayven, KLP2 593 4q21.2 87
  BTB/K6(C) NP_065854 KLHL8 620 4q21.3 88
  BTB/K6(C) NP_003624 ENC-1, Nrp/b 589 5q12-q13.3 89, 90
  BTB/K6(C) NP_059111 KLHL3 587 5q31 91, 92
  BTB/K6(C) CAC16284   634 6p12.1  
  BTB/K6(C) NP_443136 KIAA1900 620 6q16.3 93
  BTB/K6(C) NP_061334   564 7q15.3  
  BTB/K6(C) NP_055682 KIAA0711 623 8p23.2 94
  BTB/K6(?) XP_294387 *   649 8q24.13  
  BTB/K6(C) NP_005884 Calicin 588 9p11.2 95
  BTB/K6(C) NP_061335 KIAA1354 617 9p22 88
  BTB/K6(C) NP_060565   518 11p11.12  
  BTB/K6(C) AAH42952   431(a) 11q13.3  
  BTB/K6(C) NP_689646   608 11q22.3  
  BTB/K6(C) XP_044836   505 12q11.23  
  BTB/K6(C) NP_115514   684 13q13.3 96
  BTB/K6(C) NP_065917 KLHL1 748 13q21 97
  BTB/K6(C) XP_058629 *   309(b) 14q21.1  
  BTB/K6(C) NP_071925   589 15q25.2  
  BTB/K6(C) NP_079007   616 16q23.3  
  BTB/K6(C) NP_071324 gigaxonin 597 16q24.1 98
  BTB/K6(C) NP_689680 KLHL10 614 17q21.2  
  BTB/K6(C) NP_060613   708 17q21.2  
  BTB/K6(C) spQ9P2G3 * KIAA1384 628 18q12.1 88
  BTB/K6(C) NP_060786   615 19p13.11  
  BTB/K6(C) NP_036421 Keap1 624 19p13.2 98, 99
  BTB/K6(C) NP_116164   634 22q11.21  
  BTB/K6(C) NP_695002   644 Xp22.13  
  BTB/K6(C) NP_476503 KLHL4 720 Xq21.3 100
  BTB/K6(C) XP_040383 KIAA1677 604 Xq22.1-q21  
  BTB/K6(C) spQ9P2N7 KIAA1309 639 Xq23-q24  
  K6/BTBx2(N) NP_006758 LZTR-1 ^ 552 22q11.21 69
Discoidin/kelch       
  DD/K6(N) NP_037387 * muskelin 735 7q32 71
F-box/kelch       
  F-box/K5(N) XP_048774 KIAA1332 717 1p36.13  
LCM/kelch       
  LCM/K6(?) NP_055608 * p21Waf/CIPpromoter-binding protein 686 15q14 26
Kelch and PHD       
  K6/u/PHD(N) NP_000527 * RAG-2 527 11p13 16
Kelch and multidomain       
  K6/HCF/FNIII NP_005325 Host cell factor-1(N) 1938 Xq28 30
  CUB/DSL/K4? CAC12966   510 10q26.11  
  K5/CL(C) BAA25460 KIAA0543 1011 10q26 101
  K6/FNIII(N) NP_037452 Host cell factor-2 792 12q23.3 31
  CUB/K6/E(N) PIRT00209 MEGF8, pregnancy-specific β 1 glycoprotein 1737 + 19q12 102
  CB/K6/CL(N) NP_647537 * Attractin, mahogany 1198, 1429 + 20p13 27–29
Kelch and unique       
  u/K6(C) NP_689588   559 1p36.13  
  K6/u(N,?) NP_060036   520 16q24.3  
  u/K5(C) NP_612442   495 22q13.33  
Propeller only       
  K7(N) NP_060673   350 1q32.1  
  K7(N) NP_775817 *   354 3p21.21  
  K6(N,?) NP_476502 PEAS, TIM 382 6p21.1 103
  K6(C) XP_045954 KIAA0265 442 7q32.2  
  K6(N) NP_005824 p40 Rab9 effector 372 9q34.21 32
  K6(C) NP_055130 HCLP-1, Kelch domain-containing 2 406 14q21.3 104
  K6(?) NP_751943 Kelch domain-containing 1 406 14q21.3  
  1. Key. + Splice variants reported. $ No EST match. @spQ96PQ7 encodes a longer protein of 755 amino acids. ^Human LZTR-1 sequence lacks amino-terminus included in mouse NP_080084. (a), human sequence not full-length, mouse orthologue (BAB28596, >90% identity, 574aa) contains a BTB domain (b), human sequence not full-length, mouse orthologue (NP_079983, >90% identity, 571aa) contains a BTB domain. *Kelch-repeat proteins not listed in either Pfam or SMART species trees. Additional domains listed include C-type lectin (CL); C1r, C1s, uEGF, and bone morphogenetic protein domain (CUB or CB); delta serrate ligand (DSL); epidermal growth factor (EGF); fibronectin type III repeats (FNIII); HCF repeats (HCF).