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Table 2 Kelch-repeat proteins of D. melanogaster and A. gambiae

From: Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

Architecture Domain organisation GenBank Accession % Identity (Dm to Ag) Alt. name (Dros) Amino acids Closest human seq. Reference
BTB/kelch   Dros. Anop.    Dros. Anop.   
  BTB/K6 NP_724095 EAA12172* 57 Kelch 686 or1477 + 1129 Mayven 1
  BTB/K6 NP_524989 EAA05692* 94 Diablo 623 583 NP_055273  
  BTB/K6 NP_650594 EAA08775* 68   744 651 Keap1  
  BTB/K6 NP_727331 EAA12172* 67   654 698 KHLH5  
  BTB/K6 NP_650143 EAA05226* 70   575 580 NP_079286  
  BTB/K6 NP_609616 EAA14037* 66   627 618 IPP  
  BTB/K6 NP_611377 EAA13860* 78   620 614 NP_055273  
  BTB/K6 AAF45342 EAA03884* 43   474 669 KHLH10  
  BTB/K6 NP_608397     616   NP_060786  
  BTB/K6   EAA05952*     873 NS1-BP  
  K6/2xBTB NP_569869 EAA09185* 66   975 759 LZTR1  
Discoidin/kelch          
  DD/K6 NP_610801 EAA09711* 53 Muskelin 853 797 Muskelin 38
F-box/kelch          
  F-Box/K5 NP_611647 EAA00139* 41   667 580 XP_048774  
Kelch and multidomain          
  CUB/K6/EGF NP_651571 EAA05420* 64 Mahogany-like 1284 1203 Attractin  
  CUB/K6/EGF NP_609180 EAA12463* 51   2898 2811 MEGF8  
  K6/FNIII NP_726567 EAA13249* 41 HCF 1500 1396 HCF 39
Kelch and unique          
  K6/u NP_648590 EAA10380* 54   509 550 NP_060036  
Propeller          
  K6 NP_725794 EAA10479* 44 SLIM-1^ 627 373 XP_045954  
  K6 NP_572494 EAA05915* 56   403 383 PEAS/TIM  
  1. Key. + The D. melanogaster kelch gene contains two open reading frames [1], and is expressed as two isoforms, of 689 amino acids or 1477 amino acids [37]. A. gambiae EAA12172 apparently corresponds to the long form of kelch. * Kelch-repeat proteins not listed in either Pfam or SMART species trees. With the exception of NP_060786, all the most closely-related human BTB/kelch proteins are members of human BTB/kelch subgroup 1.