Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

BMC Bioinformatics

Table 2 Kelch-repeat proteins of D. melanogaster and A. gambiae

Architecture	Domain organisation	GenBank Accession		% Identity (Dm to Ag)	Alt. name (*Dros*)	Amino acids		Closest human seq.	Reference
BTB/kelch		*Dros.*	*Anop.*			*Dros.*	*Anop.*
	BTB/K6	NP_724095	EAA12172*	57	Kelch	686 or1477 +	1129	Mayven	1
	BTB/K6	NP_524989	EAA05692*	94	Diablo	623	583	NP_055273
	BTB/K6	NP_650594	EAA08775*	68		744	651	Keap1
	BTB/K6	NP_727331	EAA12172*	67		654	698	KHLH5
	BTB/K6	NP_650143	EAA05226*	70		575	580	NP_079286
	BTB/K6	NP_609616	EAA14037*	66		627	618	IPP
	BTB/K6	NP_611377	EAA13860*	78		620	614	NP_055273
	BTB/K6	AAF45342	EAA03884*	43		474	669	KHLH10
	BTB/K6	NP_608397				616		NP_060786
	BTB/K6		EAA05952*				873	NS1-BP
	K6/2xBTB	NP_569869	EAA09185*	66		975	759	LZTR1
Discoidin/kelch
	DD/K6	NP_610801	EAA09711*	53	Muskelin	853	797	Muskelin	38
F-box/kelch
	F-Box/K5	NP_611647	EAA00139*	41		667	580	XP_048774
Kelch and multidomain
	CUB/K6/EGF	NP_651571	EAA05420*	64	Mahogany-like	1284	1203	Attractin
	CUB/K6/EGF	NP_609180	EAA12463*	51		2898	2811	MEGF8
	K6/FNIII	NP_726567	EAA13249*	41	HCF	1500	1396	HCF	39
Kelch and unique
	K6/u	NP_648590	EAA10380*	54		509	550	NP_060036
Propeller
	K6	NP_725794	EAA10479*	44	SLIM-1^	627	373	XP_045954
	K6	NP_572494	EAA05915*	56		403	383	PEAS/TIM

Key. + The D. melanogaster kelch gene contains two open reading frames [1], and is expressed as two isoforms, of 689 amino acids or 1477 amino acids [37]. A. gambiae EAA12172 apparently corresponds to the long form of kelch. * Kelch-repeat proteins not listed in either Pfam or SMART species trees. With the exception of NP_060786, all the most closely-related human BTB/kelch proteins are members of human BTB/kelch subgroup 1.

ISSN: 1471-2105