Figure 14

The 22 most highly diverse superfamilies form a connected component. This subnetwork can be considered the oldest network and is the backbone of the overall network. The highly diverse superfamilies are also highly interactive as the colour coding shows (red = high connectivity). From top-left to bottom right: d.3.1, Cysteine proteinases; d.15.1, Ubiquitin-like; a.118.1, ARM repeat; d.176.1, Sulfite oxidase, middle catalytic domain; a.3.1, Cytochrome c; b.55.1, PH domain-like; a.39.1, EF-hand; b.1.1, Immunoglobulin; d.94.1, HPr-like; c.49.2, ATP syntase (F1-ATPase), gamma subunit; c.26.1, Nucleotidylyl transferase; c.10.1, RNI-like; b.69.4, Trp-Asp repeat (WD-repeat); d.153.1, N-terminal nucleophile aminohydrolases (Ntn hydrolases); a.24.11, Bacterial GAP domain; b.40.4, Nucleic acid-binding proteins; d.52.3, Prokaryotic type KH domain (pKH-domain); a.4.5, Winged helix DNA-binding domain; b.34.2, SH3-domain; b.2.5, p53-like transcription factors; a.118.2, Ankyrin repeat; c.37.1, P-loop containing nucleotide triphosphate hydrolases