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Table 2 The 19 most interactive superfamilies.

From: Visualisation and graph-theoretic analysis of a large-scale protein structural interactome

Connectivity

SCOP ID

Superfamily

46

c.37.1

P-loop containing nucleotide triphosphate hydrolases

38

b.1.1

Immunoglobulin

14

c.1.8

(Trans)glycosidases

12

d.58.1

4Fe-4S ferredoxins

11

a.3.1

Cytochrome c

11

a.4.5

Winged helix DNA-binding domain

11

c.3.1

FAD/NAD(P)-binding domain

11

d.15.4

2Fe-2S ferredoxin-like

10

b.40.4

Nucleic acid-binding proteins

10

d.142.1

Glutathione synthetase ATP-binding domain-like

9

a.39.1

EF-hand

9

c.1.4

FMN-linked oxidoreductases

9

c.2.1

NAD(P)-binding Rossmann-fold domains

8

c.55.1

Actin-like ATPase domain

8

d.144.1

Protein kinase-like (PK-like)

8

d.15.1

Ubiquitin-like

7

d.145.1

FAD-binding domain

7

d.92.1

Metalloproteases (zincins) catalytic domain