Multiple sequence alignment of parvovirus NS-1 domains found in CELO and FAdV-9. As a reference sequence, the Rep78 protein of adeno-associated virus 3B (acc. no. AAB95451) is included. JPred secondary structure prediction for CELO-ORF-2 is shown in the top line (H: alpha-helix, E: beta-sheet). Superfamily III ATPase/helicase motifs (see text) are indicated. Critical residues for NTP-binding in motif A are marked by arrows. In the region of motif A, CELO-ORF-14 and two homologous sequences from FAdV-9 were included in the alignment. In this region of CELO-ORF-14, homology to papillomavirus helicases is reported by CD-Search. As a reference sequence, papillomavirus E1 helicase (acc. no. P22154) is included. JPred secondary structure prediction for CELO-ORF-14 is shown in the bottom line.