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Archived Comments for: The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases

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  1. An ancient fold

    Shane Dillon, The Wellcome Trust Sanger Institute

    16 August 2004

    The Hotdog fold is an ancient fold that has been adapted by the three kingdoms of life. We describe a largely enzymatic superfamily that contains many proteins involved in fatty acid metabolism and other metabolic pathways. This superfamily contains several functional subfamilies and we hope that our analysis may help in identifying functions for the unknown proteins that we predict contain a Hotdog fold.

    Competing interests

    The authors declare that they have no competing interests.