Figure 6

A SN- simulator: at the beginning of the simulation. The simulation showed the actions of molecules under a biological scenario. 1. The initializing buttons synthesize molecules in each subcellular compartment. 2. The localization window shows molecules present in each subcellular compartment. In this simulation, an IgG molecule was present at the extracellular space (E.S.). There were 2 ATP molecules, an Fcγ receptor (FcγR), a Gab2 and a PIP2 (PI[4,5]P2) present at the plasma membrane (P.M.). The cytosol contained a Lyn kinase, a PI3K-p85 and a PI3K-p110 subunit. There was no molecule present at the nucleus in this simulation. 3. The "Start Simulation" button creates a previously specified translocation event. In this simulation, the translocation has already occurred and moved the IgG from the extracellular space to the plasma membrane. 4. The "Next" button triggers a search that determines a proper event to occur and advances to the next step. 5. The pathway-viewer shows a series of events occurred during the simulation.