Table 2 TABS scheme for qualitative assessment of annotation accuracy.
From: GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes
Category | Description | Comment |
|---|---|---|
0 | Total agreement | Original annotation is correct, but annotations may be only semantically (but not computationally) identical |
1 | Typographical error | Original annotation contains typographical errors that may be propagated in the database |
2 | Undefined source | Original annotation contains undefined terms, non-homology based predictions, and so on |
3 | Under-prediction | Original annotation predicts a nonspecific biochemical function although a more detailed prediction could have been made |
4 | False negative | Original annotation does not provide predicted function although there is sufficient evidence to characterize the query protein |
5 | Domain error | Original annotation overlooks different domain structure of query and reference proteins |
6 | Over-prediction | Original annotation predicts a specific biochemical function without sufficient supporting evidence |
7 | False positive | Original annotation predicts function without any supporting evidence |