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Table 1 Performance evaluation results (ROC1). Methods compared: Gapped BLAST, PSI-BLAST, prof _sim and prof _ss. For each method, the number of true family-family relationships that are detected before the first false connection occurs, is given (applied individually to each family, and summed over all families in the test set). Results are given for the following types of false connections: possible, suspicious and error (see text for details).

From: Protein family comparison using statistical models and predicted structural information

 

Number of true

family-family

relationships

detected by

 

Type of first false-relation

Gapped-BLAST

PSI-BLAST

prof _sim

prof _ss (predicted ss)

prof _ss (true ss)

Different superfamily, same fold ("possible" relationship)

163

189

231

245

391

Different fold, same class ("weak" relationship)

163

191

231

245

398

Different class ("suspicious" relationship)

174

205

253

299

483

Alpha ↔ Beta ("error" relationship)

709

690

1586

1617

1771