Table 1 Summary of Results for MDR Models Fitting (a) Three separate genotypes for all polymorphisms and (b) Using the dichotomous grouping for the polymorphisms suggested by the literature (ACE DD vs. not DD, PAI-1 presence of 4G allele vs. 5G5G, tPA II vs. not II).
# of Loci | Loci Included in Best Model | Cross-Validation Consistency | Prediction Error |
|---|---|---|---|
Fitting Three Separate Genotypes for All Polymorphisms: | |||
2 | ACE, PAI-1 | 86% | 51% |
3 | ACE, PAI-1, t-PA | 100% | 51% |
Using Dichotomous Groupings: | |||
2 | ACE, PAI-1 | 100% | 46% |
3 | ACE, PAI-1, t-PA | 100% | 46% |