Figure 2

Pattern skew of DNA sequences of different length. (A) Pattern skew (n0_4mer PS) values determined for a comprehensive collection of sequences of bacterial chromosomes, plasmids and phages are plotted against the logarithmic scale of sequence lengths. The grey shaded area depicts the 95% confidence intervals of variation of n0_4mer PS values in the complete chromosomal and plasmid sequences. Accession names of genomes been discussed in the text are presented. The genomes where the n0_4mer PS values exceeded the corresponding n1_4mer PS values by more than 2.5 σ_PS (see equation 2) are shown in red. (B) The n0_4mer PS values determined for arbitrary loci randomly cut out of the E. coli K12 (blue) and B. subtilis 168 (red) chromosome sequences are compared with PS values determined for complete bacterial chromosomes.