Table 3 Distance Matrix for PKC series in human kinome. Distance matrix for PKC series in Human Kinome. These proteins occur as a distinct branch in the phylogenetic tree of the Human Kinome. GAP results are given as percentages while SSS scores are fractions. Lower SSS scores refer to higher similarity detection. It is seen that SSS with the dynamic programming approach is able to capture phylogenetic relationships between human kinases in the PKC subfamily of proteins. F = 16, S z = 8, β = 2.5
From: Detailed protein sequence alignment based on Spectral Similarity Score (SSS)
| Â | PKCa | PKCb | PKCd | PKCe | ||||
|---|---|---|---|---|---|---|---|---|
| Â | SSS | GAP | SSS | GAP | SSS | GAP | SSS | GAP |
PKCa | 0.000 | 100 | 0.4678 | 85.949 | 0.7238 | 61.835 | 0.7391 | 63.851 |
PKCb | 0.4678 | 85.949 | 0.000 | 100 | 0.7254 | 61.029 | 0.6904 | 62.944 |
PKCd | 0.7238 | 61.835 | 0.7254 | 61.029 | 0.000 | 100 | 0.7149 | 55.472 |
PKCe | 0.7391 | 63.851 | 0.6904 | 62.944 | 0.7149 | 55.472 | 0.000 | 100 |
PKCg | 0.5137 | 81.081 | 0.5951 | 79.464 | 0.7348 | 60.589 | 0.7550 | 61.695 |
PKCh | 0.7160 | 64.794 | 0.7371 | - | 0.7371 | 53.506 | 0.6146 | 76.035 |
PKCi | 0.7498 | 52.072 | 0.7568 | 50.357 | 0.7338 | 45.098 | 0.7599 | 52.909 |
PKCt | 0.7113 | 61.847 | 0.7474 | 59.370 | 0.6068 | 73.333 | 0.7451 | 55.043 |