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Table 2 Distribution of poly (dA.dT) repeats of various lengths in the 5' upstream regions of housekeeping and tissue specific genes.

From: Comparative analysis of chromatin landscape in regulatory regions of human housekeeping and tissue specific genes

Poly (dA.dT) stretch (bp)

No. of repeat stretches in the two classes

No. of genes with repeats in 5' region (%)

 
 

Hkg #

Tsg*

Hkg #

Tsg*

§ P -value

>10

443

345

268 (51.0)

240 (43.0)

1.31E-04

>11

381

297

243 (46.3)

214 (38.4)

3.25E-04

>12

339

248

226 (43.1)

184 (33.0)

6.10E-05

>13

295

207

209 (39.8)

156 (28.0)

4.29E-05

>14

251

168

188 (35.8)

128 (22.9)

2.77E-05

>15

209

140

164 (31.2)

111 (19.9)

8.83E-05

>16

180

116

146 (27.8)

99 (17.7)

7.58E-05

>17

155

103

134 (25.5)

88 (15.8)

2.42E-04

>18

138

79

120 (22.9)

71 (12.7)

2.23E-05

>19

112

66

101 (19.2)

59 (10.6)

2.61E-04

>20

100

58

92 (17.5)

53 (9.5)

5.32E-04

  1. #Housekeeping genes, *Tissue specific genes. A total of 525 housekeeping and 558 tissue specific genes were analysed. The numbers in parentheses (4th & 5th columns) represent the percentage of genes containing the repeat stretch.
  2. §Difference in the distribution of poly (dA.dT) stretches in Hkg and Tsg analysed by applying t-test (for normalizing the difference in sample size). The repeat lengths from >12 to >18 bp are showing very significantly different distributions between Hkg and Tsg. The distributions were examined in 2000 bp upstream region from the gene start site.