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Table 1 Results from GENERATOR with H2O2 dataset using five clusters. The table shows the reported classes for five clusters from GENERATOR clustering shown in figure 1. The three over-representation values described in Methods section and figure 5 are reported for each class. Results are also compared to graphical output from SGD GO term finder (figure 8 [see Additional file 3]). Abbreviations in this column are: MF, molecular function; CC, cellular component; BP, biological process. Classes reported as 'missing' were not observed in the SGD GO term finder graphs. A more detailed view of the data is available in table 5 [see Additional file 5]. Classes with S.log(p) < 1 (marked with -) are not included to analysis although they are still shown here.

From: Theme discovery from gene lists for identification and viewing of multiple functional groups

CLUSTER

FUNCTIONAL CLASS

C.log(p)

O.log(p)

S.log(p)

SGD

I

organellar ribosome

46.7

26.1

21

CC

 

mitochondrial ribosome

46.7

26.1

21

CC

 

mitochondrial matrix

41.6

30.5

14.9

CC

 

Ribosome

36.9

14.5

23.7

CC

 

structural constituent of ribosome

35.9

14.8

22.3

MF

II

RNA ligase activity

13.3

6.68

6.64

MF

 

tRNA ligase activity

13.3

6.68

6.64

MF

 

ligase activity, forming aminoacyl-tRNA and related compounds

13.3

6.68

6.64

MF

 

ligase activity, forming carbon-oxygen bonds

13.3

6.68

6.64

MF

 

ligase activity, forming phosphoric ester bonds

13

6.42

6.64

MF

III

mitochondrial membrane

13.9

3.66

11

CC

 

inner membrane

13.1

3.99

9.6

CC

 

mitochondrial inner membrane

13.1

3.99

9.6

CC

 

Mitochondrion

8.91

40.1

1.03

-

 

respiratory chain complex III

8.03

4.32

3.74

CC

IV

transcription regulator activity

12.3

2.52

11.5

MF

 

nucleobase, nucleoside, nucleotide and nucleic acid metabolism

8.99

2.15

7.51

BP

 

mediator complex

8.97

5.15

3.88

Missing

 

general RNA polymerase II transcription factor activity

7.94

4.16

3.88

MF

 

DNA-directed RNA polymerase II, holoenzyme

7.81

4.04

3.88

Missing

V

mitochondrial genome maintenance

7.22

5.97

2.02

Missing

 

mitochondrion organization and biogenesis

6.74

4.06

3.05

Missing

 

mitochondrial chromosome

4.23

3.18

1.05

- (CC)

 

soluble fraction

3.1

2.52

1.09

-

 

helicase activity

3

3.35

0.79

-