Table 4 Pathway significance. This table shows the number of samples (out of 117) in the van 't Veer data set with pathway status active (+) or inactive (-) and with Group Sample Score p-value ≤ 0.05. Also shown are the corresponding family-wise p-values. ER notation as in Table 1.
From: Signal transduction pathway profiling of individual tumor samples
Pathway | + | - | family-wise p-value |
|---|---|---|---|
ER-induced | 30 | 37 | 2e-55 |
EDAR | 30 | 30 | 6e-46 |
IL-1 | 25 | 34 | 1e-44 |
RANK | 29 | 30 | 1e-44 |
TNF-α | 29 | 29 | 2e-43 |
EGF network | 29 | 29 | 2e-43 |
ER | 28 | 29 | 4e-42 |
ER-induced(v) | 21 | 34 | 1e-39 |
TLR4 | 28 | 27 | 1e-39 |
fMLP | 24 | 31 | 1e-39 |
Insulin | 22 | 21 | 6e-26 |
ER (v) | 17 | 21 | 6e-21 |
TGFβ network | 20 | 18 | 6e-21 |
c-Kit | 20 | 14 | 3e-17 |
ER-repressed (v) | 11 | 17 | 4e-12 |
VEGF | 11 | 15 | 1e-10 |
IL-10 | 12 | 13 | 7e-10 |
IFN | 11 | 14 | 7e-10 |
PRL | 11 | 14 | 7e-10 |
TPO | 10 | 14 | 3e-09 |
PDGF | 9 | 12 | 4e-07 |
Oncostatin M | 6 | 15 | 4e-07 |
T-cell antigen receptor | 11 | 8 | 6e-06 |
B-cell antigen receptor | 11 | 7 | 2e-05 |
IL-12 – STAT4 | 7 | 9 | 2e-04 |
ER-repressed | 7 | 6 | 6e-03 |
IL-2 – STAT5 | 5 | 7 | 1e-02 |
IL-4 – STAT6 | 5 | 3 | 2e-01 |
Wnt | 4 | 4 | 2e-01 |