Figure 2

Lack of the alignment consensus may reflect a structural divergence of the motif. One of the α-helices (light color) displays a considerable difference in orientation in the two superimposed structures, target T0282 and the template 1gq6. All other regions of the structures are assigned the color gradient ranging from blue (N-termini) to red (C-termini). The lower part of the figure shows this α-helix and adjacent regions of T0282 aligned with 1gq6 according to both structural correspondence (dali) and a consensus alignment produced by PSI-BLAST-ISS (iss). The secondary structure of the target T0282 is shown above the sequence alignment.