Lack of the alignment consensus in a structurally conserved region due to variable adjacent regions. Structural superposition of T0247 with the template 1pj5. The considered T0247 α-helix (white) superimposes fairly closely with the corresponding α-helix (light yellow) in 1pj5, but has an insertion at one end and a deletion at the other end. The lower part of the figure shows the α-helix and adjacent regions of T0247 aligned with the corresponding fragment of the 1pj5 sequence. For the 1pj5 sequence the structure-based alignment (dali), the PSI-BLAST-ISS consensus alignment (iss), two individual PSI-BLAST-ISS alignment variants (iss_var1 and iss_var2) and the Consensus server alignment (cons_srv) are shown. The alignment obtained by the Consensus server includes only residues considered to be aligned confidently (residues assigned to 'S'). The secondary structure diagram for T0247 is also shown above the sequence alignment.