Figure 1

PDB data coverage and overlap of three interface identification methods. Numbers in a circle represent the number of PDB entries whose interfaces have been identified according to ASA (green), PSIMAP (red), and Voronoi (blue) methods. In the case of multidomain proteins, 24, 474, and 403 PDB entries are exclusively identified by ASA, PSIMAP, and Voronoi method, respectively. The main reason for the exclusive detection results from the different method of interface identification. Interfaces from 298 PDB entries, uniquely identified by the ASA method, are not domain-domain interfaces. They are interfaces between a domain and DNA (RNA), or between a domain and non-domain region from a different chain. The numbers are based on SCOP 1.65. All the PDB entries that belong to each category are downloadable on the InterPare website.